28-7 careers


We are working on cutting-edge biology, based on the breakthrough science of our world renowned scientific founders. We are looking for passionate researchers who are as excited as we are about the future of treating human disease. If you are an expert scientist in RNA and/or cancer biology, or on your way to become one, we are interested in hearing from you!


SCIENTIST/SENIOR SCIENTIST

We have an immediate opening for a full-time Scientist / Senior Scientist to join our growing Biology team. This individual will utilize their strong lab-based technical expertise and critical thinking skills to support the company’s primary drug discovery efforts, as well as contribute intellectually to pipeline expansion. We are offering a competitive salary and benefits package for an individual with the following qualifications and experience:

Responsibilities

  • Drive biology efforts and support strategic direction for our flagship program

  • Application of cell and molecular biology techniques including, but not limited to, genome editing techniques, qPCR, Western blot, and 2D/3D cell-based phenotypic read-outs

  • Lead the experimental design, execution, and interpretation of results to support preclinical and translational goals

  • Evaluate and implement technologies relevant for our novel area of drug discovery in RNA biology

  • Directly manage contract research organizations (CRO) for outsourced activities

  • Participate in and present results at internal group meetings

Qualifications

  • Ph.D. with 2-5 years, M.S. with 7+ years, or B.S. with 10+ years relevant drug discovery experience in molecular biology or related field

  • Demonstrated scientific rigor in cancer biology and/or RNA-dependent regulatory mechanisms

  • Strong oral and written communication skills, with attention to detail

  • Proven team player among cross-functional disciplines

  • Motivated, independent self-starter comfortable in a dynamic, fast-paced start-up environment

  • Immunology, immune-oncology, and/or bioinformatics experience also a plus

Please send resumes and any other supporting materials to:

Sarah Knutson
Director, Pre-clinical Biology
Twentyeight-Seven Therapeutics
sknutson@28-7tx.com


Principal Scientist/Associate Director of Medicinal Chemistry

Twentyeight-Seven Therapeutics is seeking a full-time Principal Scientist/Associate Director of Medicinal Chemistry to join our team, reporting to the Senior Director of Chemistry. The individual will be responsible for independently developing and implementing medicinal chemistry strategies that efficiently solve complex research problems and successfully enable achievement of pivotal corporate goals and delivering high-quality development candidates. We are offering a competitive salary and benefits package for an individual with the following qualifications and experience:

Responsibilities:

  • Independently design and manage the external, synthesis, purification and characterization of novel chemical entities, from identification of initial chemical matter through progression to a development candidate

  • Independently implement medicinal chemistry strategies to address critical project issues in a multi-parametric / holistic manner

  • Collaborate and interact with biology project leads and other functional areas within the company to achieve project goals

  • Manage and collaborate external CROs to accomplish project and corporate goals

  • Effectively communicate project updates across the organization and maintain excellent records, ensure data integrity and transparency within the team

Qualifications:

  • Ph.D. in chemistry with 7-10 years’ experience in the pharmaceutical or biotechnology industry

  • Track record of innovation and creative problem solving as evidenced by the design of multiple compounds that have entered clinical testing

  • Familiarity with modern methods in medicinal and organic chemistry, including lead generation, lead optimization, compound selection and progression

  • Ability to apply chemical informatics and other computational tools to lead discovery and optimization

  • Comprehensive understanding of applying molecular properties, DMPK concepts and pharmacodynamics responses to the discovery of high-quality clinical candidates

  • Understanding of contemporary research problems and approaches within cancer drug discovery highly desired

  • Demonstrated ability to interact effectively across boundaries with other functions using influence and relationship building skills

  • Proven leadership skills, strong problem-solving skills requiring the highest application of scientific theory or technical methodology

  • Desire to work in fast paced, scientifically rigorous environment

  • Demonstrated sense of urgency in meeting aggressive, time sensitive goals

  • Outstanding written, communication, and presentation skills

Please send resumes and any other supporting materials, to:

Darren Harvey
Senior Director, Chemistry
Twentyeight-Seven Therapeutics
dharvey@28-7tx.com