Our Therapies Restore Balance

We have set our first sights on cancer, an incredibly difficult disease to cure, dynamically evolving against the drugs used to treat it.  Despite annual approvals of new cancer therapies, cancer remains the second leading cause of death in the U.S.1

Unfortunately, relapse is common.  Over time, a cancer can activate multiple processes to become more and more aggressive, and potentially resist multi-drug regimens.2

1 Centers for Disease Control, 2017 2 Hanahan & Weinberg, Cell, 2011

Many Pathways to Cancer

Evading growth suppressors
Avoiding immune destruction
Enabling replicative immortality
Tumor- promoting inflammation
Activating Invasion & metastasis
Induction of angiogenesis
Genome instability & mutation
Resisting cell death
Deregulating cellular energetics
Sustaining proliferative signaling

Our Multi-Pathway Therapeutic Strategy

Most cancer drugs work by shutting down a single cellular pathway to halt or slow the growth of a cancer cell.  However, cancer cells use many oncogenic pathways to maintain their aggressive growth and can activate new pathways over time.  These cellular pathways may also be used, but to a lesser extent, by healthy cells, so patients may suffer from potentially severe drug toxicities by the very drugs intended to treat their cancer.

Our therapeutic goal is fundamentally different.  Our first program is designed to amplify multiple pathways that maintain a cell’s normal, differentiated phenotype.  In a cancer cell context, activating these pathways reverses tumor growth.  In other words, we are fighting cancer by restoring a healthy state.