Our Therapies Restore Balance

Nucleic acid (both RNA and DNA) processing and signaling are fundamental regulators to maintain cellular homeostasis, including metabolism, differentiation, and responses to external stimuli.  Many of these regulators are enzymes that are involved in important cellular processes such as RNA splicing, RNA or DNA stability, RNA or DNA sensing, replication, and repair.

Certain of these nucleic acid regulators or pathways can become dysregulated and lead to serious diseases such as cancer and autoimmune diseases.  The mission of Redona is to develop innovative small-molecule therapeutics to address dysregulated nucleic acid processes and thereby restore appropriate cellular homeostasis and lead to clinical benefit to patients.

Many Pathways to Cancer and Autoimmune Diseases

Diseases such as cancer and autoimmune diseases are complex, and therefore shutting down a single cellular target or pathway to halt or slow the disease, particularly in cancer, often has profound limitations.  Cancer cells use many oncogenic pathways to maintain their aggressive growth and can activate new pathways to overcome the therapies that are being used to treat the tumor.

Our therapeutic goal in cancer is to develop small-molecule drugs against nucleic acid regulators which in turn can impact multiple hallmarks of cancer.  New cancer hallmarks being considered, such as aberrant RNA splicing, represent our mission to forge new paths to develop novel therapies that are intended to be more robust and durable than the current standard of care.

Evading growth suppressors
Avoiding immune destruction
Enabling replicative immortality
Tumor- promoting inflammation
Activating Invasion & metastasis
Induction of angiogenesis
Genome instability & mutation
Resisting cell death
Deregulating cellular energetics
Sustaining proliferative signaling